Pair Name	Sanguinarium, Bortezomib
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Activity	CASP3	hsa836
	Down-regulation	Activity	CASP9	hsa842
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	JAK2	hsa3717
	Down-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	PTPN6	hsa5777
	Down-regulation	Expression	STAT3	hsa6774
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	U266B1	Plasma cell myeloma	Homo sapiens (Human)	CVCL_0566
	MM1.S	Plasma cell myeloma	Homo sapiens (Human)	CVCL_8792
Result	Our findings demonstrate that SNG induces mitochondrial and caspase-dependent apoptosis, generates oxidative stress, and suppresses MM cell lines proliferation. In addition, co-treatment of MM cell lines with sub-toxic doses of SNG and BTZ potentiated the cytotoxic activity. These results would suggest that SNG could be developed into therapeutic agent either alone or in combination with other anticancer drugs in MM.